Since the dawn of civilization, humankind has sought various ways to alter its consciousness, its experiences, and its perceptions. The methods and mediums with which we can do this are nearly endless. From betel nut, a spicy nut that’s chewed as a stimulant in many cultures in Central and Southeast Asia, to speedballing, injecting a mixture of heroin and cocaine, human ingenuity has seemingly never run out of ways to transform its psyche, whether for spiritual reasons or just for a few hours of recreation. Many cultures throughout history have used drugs and alcohol symbolically and spiritually, reveling in the loss of the self that comes with the use of psychoactive substances. Over the course of the last century and a half, however, the cultural zeitgeist in many nations has been to outlaw a lot of these substances in favor of a much more sober, stoic approach to life one guided more by following rules than bending them. Here are ten illegal drugs and their histories.